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KMID : 0352419950140030221
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Keimyung Medical Journal
1995 Volume.14 No. 3 p.221 ~ p.230
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Effects of βAdrenoceptor Blockers on Ischemia-Reperfusion Injury in Rat Heart
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Abstract
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The effects of βadrenoceptor blockers(metoprolo, acebutolol, and atenolol) on the biochemical changes occurring following ischemia(60min) and reperfusion(20min) were examined in the isolated Langendorff perfused rat heart after chronic
adriamycin(1mg/kg/day, i. p. for 4wks) treatment. The purpose of this study was to investigate whether the protections of βadrenergic blockers would be involved in ischemia-reperfusion injury of chronic adriamycin treated rat heart. The
βadrenoceptor
blockers showed the decrease of lactate dehydrogenase(LDH) activity and malondialdehyde(MDA) content and the no significance of superoxide dismutase(SOD) activity. Metoprolol and atenolol exhibited the increase of LDH activity in dose dependent.
Our results indicate that the significant protection is not observed by increasing the doses of metoprolol, acebutolol, and atenolol and appear to be independence on the doses of βadrenoceptor blockers in chronic free radical injured rat heart.
Acebutolol which has the membrane stabilizing activity shows relative protective effect on the cardiac damage comparing with metoprolol and atenolol.
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